2020年十大新兴技术(全文完整)

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2020年十大新兴技术(全文完整)

 

 Illustrations:

 V anessa

 Branchi

 Contents

 3 Intr oduction

  4 1

 Micr oneedles

 for

 Painless

 Injections

 and

 T ests

  6

 2

 Sun-Powered

 Chemistry

  8

 3

 V irtual

 Patients

  10

 4

 Spatial

 Computing

  12

 5

 Digital

 Medicine

  14

 6

 Electric

 Aviation

  16

 7

 Lower-Carbon

 Cement

  18

 8

 Quantum

 Sensing

  20

 9

 Green

 Hydrogen

  22

 10

 Whole-Genome

 Synthesis

  24

 Acknowledgements

  ©

 2020

 W orld

 Economic

 Forum.

 All

 rights reserved.

 No

 part

 of

 this

 publication

 may be

 r eproduced

 or

 transmitted

 in

 any

 form or

 by

 any

 means,

 including

 photocopying and

 r ecording,

 or

 by

 any

 information storage

 and

 retrieval

 system.

 T op

 10

 Emerging T echnologies

 of

 2020

 3

 November 2020

 T op

 10

 Emerging T echnologies

 of

 2020

 Intr oduction

 Experts

 highlight

 advances

 with

 the

 potential

 to

 revolutionize

 industry, healthcar e

 and

 society

 The gr oup, convened

 by Scientific

 American and

 the

 W orld Economic

 Forum, sifted

 thr ough mor e

 than

 75 nominations.

 If

 some

 of

 the

 many

 thousands

 of

 human

 volunteers needed

 to test

 cor onavirus

 vaccines

 could

 have been

 r eplaced

 by

 digital

 replicas

 –

 one

 of

 this

 year’s

 T op 10

 Emerging

 T echnologies

 –

 COVID-19 vaccines

 might

 have

 been

 developed

 even

 faster , saving

 untold

 lives.

 Soon

 virtual

 clinical

 trials

 could be

 a

 r eality

 for

 testing

 new

 vaccines

 and

 therapies. Other

 technologies

 on

 the

 list

 could

 r educe gr eenhouse

 gas

 (GHG)

 emissions

 by

 electrifying

 air travel

 and

 enabling

 sunlight

 to directly

 power

 the production

 of

 industrial

 chemicals.

 With

 “spatial” computing,

 the

 digital

 and

 physical

 worlds

 will

 be

 integrated

 in

 ways

 that

 go

 beyond

 the

 feats of

 virtual

 r eality.

 And

 ultrasensitive

 sensors

 that exploit

 quantum

 pr ocesses

 will

 set

 the

 stage

 for

 such

 applications

 as

 wearable

 brain

 scanners

 and vehicles

 that

 can

 see

 ar ound

 cor ners.

 These

 and

 the

 other

 emerging

 technologies

 have been

 singled

 out

 by

 an

 international

 steering

 group of

 experts.

 The

 group,

 convened

 by

 Scientific American

 and

 the

 W orld

 Economic

 Forum,

 sifted through

 mor e

 than

 75

 nominations.

 T o

 win

 the nod,

 the

 technologies

 must

 have

 the

 potential

 to spur

 progr ess

 in

 societies

 and

 economies

 by outperforming

 established

 ways

 of

 doing

 things. They

 also

 need

 to be

 novel

 (that

 is,

 not

 curr ently

 in wide

 use)

 yet

 likely

 to have

 a

 major

 impact

 within the

 next

 thr ee

 to five

 years.

 The

 steering

 group

 met (virtually)

 to whittle

 down the

 candidates

 and

 then closely

 evaluate

 the

 fr ont-runners

 befor e

 making

 the final

 decisions.

 W e

 hope

 you

 are

 as

 inspir ed

 by

 the r eports

 that

 follow

 as

 we

 ar e.

 Author

 Elizabeth O’Day

 MEDICINE

  Micr oneedles

 for Painless

 Injections and

 T ests

 Fewer

 trips

 to

 medical

 labs

 make car e

 mor e

 accessible

 1

  The needles’ temporary

 gentle perforation

 of

 the skin

 enhances passage

 of

 the therapeutic

 agent.

 Bar ely

 visible

 needles,

 or

 “micr oneedles”,

 are poised

 to usher

 in

 an

 era

 of

 pain-fr ee

 injections and

 blood

 testing.

 Whether

 attached

 to a

 syringe or

 a

 patch,

 micr oneedles

 pr event

 pain

 by

 avoiding contact with

 nerve

 endings.

 T ypically

 50-2,000 microns

 in

 length

 (about

 the

 depth

 of

 a

 sheet

 of

 paper),

 and

 1-100 microns

 wide

 (about

 the width

 of

 human

 hair),

 they

 penetrate

 the

 dead

 top layer

 of

 skin

 to reach

 into

 the

 second

 layer

 –

 the epidermis

 –

 consisting

 of

 viable

 cells

 and

 a

 liquid known

 as

 interstitial

 fluid.

 But

 most

 do not

 reach, or

 only

 bar ely

 touch,

 the

 underlying

 dermis

 wher e the

 nerve

 endings

 lie,

 along

 with

 blood

 and

 lymph vessels

 and

 connective

 tissue.

  Many

 micr oneedle

 syringe

 and

 patch

 applications are

 alr eady

 available

 for

 administering

 vaccines and

 many

 mor e

 are

 in

 clinical

 trials

 for

 use

 in tr eating

 diabetes,

 cancer

 and

 neur opathic

 pain.

 Because

 these

 devices

 insert

 drugs

 directly

 into

 the epidermis

 or

 dermis,

 they

 deliver

 medicines

 much mor e

 ef ficiently

 than

 familiar

 transdermal

 patches, which

 r ely

 on

 diffusion

 through

 the

 skin.

 This

 year researchers

 debuted

 a

 novel

 technique

 for

 tr eating skin

 disorders

 such

 as

 psoriasis,

 warts

 and

 certain types

 of

 cancer:

 mixing

 star -shaped

 micr oneedles into

 a

 therapeutic

 cr eam

 or

 gel.

 The

 needles’ temporary

 gentle

 perforation

 of

 the

 skin

 enhances passage

 of

 the

 therapeutic

 agent.

  Many

 micr oneedle

 pr oducts are

 moving

 towards commer cialization

 for

 rapid,

 painless

 draws

 of blood

 or

 interstitial

 fluid

 and

 for

 use

 in

 diagnostic testing

 or

 health

 monitoring.

 Tiny

 holes

 made

 by the

 needles

 induce

 a

 local

 change

 in

 pr essur e

 in the

 epidermis

 or

 dermis

 that

 for ces

 interstitial

 fluid or

 blood

 into

 a

 collection

 device.

 If

 the

 needles

  are

 coupled

 to biosensors,

 the

 devices

 can,

 within minutes,

 directly

 measur e

 biological

 markers indicative

 of

 health

 or

 disease

 status,

 such

 as glucose,

 cholesterol,

 alcohol,

 drug

 by-products or immune

 cells.

 Some

 pr oducts would

 allow

 the

 draws

 to be done

 at

 home

 and

 mailed

 to a

 lab

 or

 analysed

 on

 the

 spot. At

 least

 one

 pr oduct has

 alr eady clear ed

 regulatory

 hurdles

 for

 such

 use.

 The United

 States

 and

 Eur ope

 recently

 approved

 the T AP

 blood

 collection

 device

 fr om

 Seventh

 Sense Biosystems,

 which

 enables

 lay

 people

 to collect

 a

 small

 sample

 of

 blood

 on

 their

 own,

 whether

 for sending

 to a

 lab

 or

 for

 self-monitoring.

 In

 resear ch settings,

 micr oneedles

 are

 also

 being

 integrated with

 wir eless

 communication

 devices

 to measur e a

 biological

 molecule,

 use

 the

 measur ement

 to determine

 a

 proper

 drug

 dose

 and

 then

 deliver

 that

 dose

 –

 an

 approach

 that

 could

 help

 r ealize

 the pr omise

 of

 personalized

 medicine.

  Micr oneedle

 devices

 could

 enable

 testing

 and tr eatment

 to be

 deliver ed

 in

 underserved

 ar eas because

 they

 do not

 requir e

 costly

 equipment

 or a

 lot

 of

 training

 to administer . Micron

 Biomedical has

 developed

 one

 such

 easy-to-use

 device:

 a

 bandage-sized

 patch

 that

 anyone

 can

 apply. Another

 company,

 V axxas,

 is

 developing

 a micr oneedle

 vaccine

 patch

 that

 in

 animal

 and

 early

 human

 testing

 elicited

 enhanced

 immune responses

 using

 a

 mer e

 fraction

 of

 the

 usual

 dose.

 Micr oneedles

 can

 also

 r educe

 the

 risk

 of

 transmitting blood-bor ne

 viruses

 and

 decr ease

 hazar dous

 waste fr om

 the

 disposal

 of

 conventional

 needles.

  Tiny

 needles

 are

 not

 always

 an

 advantage;

 they

 will

 not

 suffice

 when

 large

 doses

 are

 needed.

 Not all

 drugs

 can

 pass

 through

 micr oneedles,

 nor

 can all

 bio-markers

 be

 sampled

 through

 them.

 Mor e resear ch

 is

 needed

 to understand

 how

 factors

 such

 as

 the

 age

 and

 weight

 of

 the

 patient,

 the

 site of

 injection

 and

 the

 delivery

 technique

 influence

 the ef fectiveness

 of

 microneedle-based

 technologies. Still,

 these

 painless

 prickers

 can

 be

 expected

 to significantly

 expand

 drug

 delivery

 and

 diagnostics and

 new

 uses

 will

 arise

 as

 investigators

 devise ways

 to use

 them

 in

 organs

 beyond

 the

 skin.

  Micr oneedles

 ar e

 typically 1-100 micr ons

 wide

 (about the

 width

 of

 human hair).

 Author

 Javier Gar cia

 Martinez

  CHEMICAL

  ENGINEERING

  Sun-Power ed Chemistry

 V isible

 light

 can

 drive

 pr ocesses that

 convert

 carbon

 dioxide

 into common

 materials

 2

 A new

 appr oach employs

 sunlight to

 convert

 waste carbon

 dioxide into

 these

 needed chemicals.

 The

 manufactur e

 of

 many

 chemicals

 important to human

 health

 and

 comfort consumes

 fossil

 fuels,

 thereby

 contributing

 to extractive

 processes, carbon

 dioxide

 emissions

 and

 climate

 change.

 A new

 approach

 employs

 sunlight

 to convert

 waste carbon

 dioxide

 into

 these

 needed

 chemicals, potentially

 r educing

 emissions

 in

 two ways

 –

 by using

 the

 unwanted

 gas

 as

 a

 raw

 material,

 and sunlight,

 not

 fossil

 fuels,

 as

 the

 source

 of

 energy needed

 for

 production.

  This

 process

 is

 becoming

 incr easingly

 feasible thanks

 to advances

 in

 sunlight-activated

 catalysts, or

 photocatalysts.

 In

 r ecent

 years,

 investigators have

 developed

 photocatalysts

 that

 br eak

 the resistant

 double

 bond between

 carbon

 and oxygen

 in

 carbon

 dioxide.

 This

 is

 a

 critical

 first

 step

 in

 cr eating

 “solar”

 r efineries

 that

 produce useful

 compounds

 fr om

 the

 waste

 gas

 –

 including “platform”

 molecules

 that

 can

 serve

 as

 raw materials

 for

 the

 synthesis

 of

 such

 varied

 pr oducts as

 medicines,

 detergents,

 fertilizers

 and

 textiles.

  Photocatalysts

 are

 typically

 semiconductors,

 which requir e

 high-energy

 ultraviolet

 light

 to generate

 the

 electr ons

 involved

 in

 the

 transformation

 of carbon

 dioxide.

 Y et

 ultraviolet

 light

 is

 both scarce (r epr esenting

 just

 5%

 of

 sunlight)

 and

 harmful.

 The development

 of

 new

 catalysts

 that

 work under

 mor e abundant

 and

 benign

 visible

 light

 has

 therefor e

 been a

 major

 objective.

 That

 demand

 is

 being

 addr essed by

 car eful

 engineering

 of

 the

 composition,

 structur e and

 morphology

 of

 existing

 catalysts,

 such

 as titanium

 dioxide.

 Although

 it

 ef ficiently

 converts carbon

 dioxide

 into

 other

 molecules

 solely

 in response

 to ultraviolet

 light,

 doping

 it

 with

 nitr ogen gr eatly

 lowers

 the

 energy

 requir ed

 to do so.

 The

 alter ed

 catalyst

 now

 needs

 only

 visible

 light

 to yield

 widely

 used

 chemicals

 such

 as

 methanol, formaldehyde

 and

 formic

 acid

 –

 collectively important

 in

 the

 manufactur e

 of

 adhesives,

 foams, plywood,

 cabinetry,

 flooring

 and

 disinfectants.

  At

 the

 moment,

 solar

 chemical

 resear ch

 is occurring

 mainly

 in

 academic

 laboratories, including

 at

 the

 Joint

 Center...

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